teratogenic effect of lippia citriodora leaves aqueous extract in mice

نویسندگان

zahra oskouei shirvan departments of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

leila etemad pharmaceutical research center, mashhad university of medical sciences, mashhad, iran

reza zafari departments of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

seyed adel moallem departments of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

چکیده

objective: safety of lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. this study aimed to identify the effect of l. citriodora aqueous extract on pregnancy outcome in mice. materials and methods: timed-pregnant mice received doses of 0.5 g/kg/day l. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. maternal body weights were measured throughout the pregnancy. the litters were examined for external malformations and skeletal abnormalities. fetuses were stained with alizarin red s and alcian blue. results: there were no significant differences in mean maternal weight gain during pregnancy between groups. also, no significant differences were observed in mean number of implantation, live and resorbed fetuses between control and treated groups. the prevalence of all types of deformity was low and similar to control group (%1.11). conclusion: the results of this study show that moderate consumption of l. citriodora as an infusion or tea appears to be safe to be used during pregnancy and does not have toxic effects on development of mouse embryo.

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منابع مشابه

Teratogenic effect of Lippia citriodora leaves aqueous extract in mice

OBJECTIVE Safety of Lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. This study aimed to identify the effect of L. citriodora aqueous extract on pregnancy outcome in mice. MATERIALS AND METHODS Timed-pregnant mice received doses of 0.5 g/kg/day L. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. Maternal body weights wer...

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Teratogenic effect of Lippia citriodora leaves aqueous extract in mice

Objective: Safety of Lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. This study aimed to identify the effect of L. citriodora aqueous extract on pregnancy outcome in mice. Materials and Methods: Timed-pregnant mice received doses of 0.5 g/kg/day L. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. Maternal body weights wer...

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Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice

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Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice

Verbascoside (acteoside), a phenyl propanoid glycoside, comprises 0.5 to 3.5% dry weight of Lippia citriodora leaves. A wide range of biological activities are attributed to verbascoside including anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anti-fungal, photoprotective as well as chelating effects. The objective of this study is to evaluate the effect of verbascoside on pregnanc...

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Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice

Verbascoside (acteoside), a phenyl propanoid glycoside, comprises 0.5 to 3.5 % dry weight of Lippia citriodora leaves. A wide range of biological activities are attributed to verbascoside including anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anti-fungal, photoprotective as well as chelating effects. The objective of this study is to evaluate the effect of verbascoside on pregnan...

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teratogenic effect of verbascoside, main constituent of lippia citriodora leaves, in mice

verbascoside (acteoside), a phenyl propanoid glycoside, comprises 0.5 to 3.5% dry weight of lippia citriodora leaves. a wide range of biological activities are attributed to verbascoside including anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anti-fungal, photoprotective as well as chelating effects. the objective of this study is to evaluate the effect of verbascoside on pregnanc...

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عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۶، شماره ۲، صفحات ۱۷۵-۱۸۰

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